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http://dx.doi.org/10.1002/aet2.10715 | DOI Listing |
J Comput Chem
January 2025
Department of Organic Chemistry, Taras Shevchenko National University of Kyiv, Kyiv, Ukraine.
Lipophilicity and acidity/basicity are fundamental physical properties that profoundly affect the compound's pharmacological activity, bioavailability, metabolism, and toxicity. Predicting lipophilicity, measured by (1-octanol-water distribution coefficient logarithm), and acidity/basicity, measured by (negative of acid ionization constant logarithm), is essential for early drug discovery success. However, the limited availability of experimental data and poor accuracy of standard and assessment methods for saturated fluorine-containing derivatives pose a significant challenge to achieving satisfactory results for this compound class.
View Article and Find Full Text PDFData Brief
February 2025
Biomedical Optics, Rawalpindi Medical University, Rawalpindi 46000, Pakistan.
is a well-known opportunistic pathogen, responsible for various nosocomial infections. UOL-KIMZ-24 was previously isolated from a clinical specimen, collected from Lahore General Hospital, Lahore (LGH), Pakistan, dated 3rd March, 2022. During the initial screening for antimicrobial susceptibility, the UOL-KIMZ-24 was found a multiple drug resistant (MDR) strain.
View Article and Find Full Text PDFHeliyon
January 2025
Rutgers Global Health Institute, Rutgers School of Public Health, New Brunswick, NJ, USA.
Background: A war has a catastrophic effect on veterans' health. However, there is a knowledge gap about the veterans' rehabilitation system, requirements, and the satisfaction of doctor-organizers. The present study aims to assess the level of satisfaction of the doctor-organizers of health care with the existing rehabilitation system for anti-terrorist operation (ATO) veterans in Ukraine.
View Article and Find Full Text PDFEnviron Res
January 2025
School of Remote Sensing & Geomatics Engineering, Nanjing University of Information Science & Technology, No.219, Ningliu Road, Nanjing, 210044, Jiangsu, China.
Heat extremes become increasingly frequent and severe, posing adverse risks to public health and environment. Previous research on extreme heat mostly used meteorological observations or reanalysis data, which cannot well capture detailed spatial patterns. This study developed a seamless air temperature (T) dataset from remote sensing data to characterize the spatio-temporal variations of heat extremes in the Yangtze River Delta (YRD) from 2001 to 2023.
View Article and Find Full Text PDFBiotechnol Adv
January 2025
Key Laboratory of Coastal Biology and Biological Resource Utilization, Yantai Institute of Coastal Zone Research, Chinese Academy of Sciences, Yantai 264003, Shandong, China. Electronic address:
The global market demand for natural astaxanthin (AXT) is growing rapidly owing to its potential human health benefits and diverse industry applications, driven by its safety, unique structure, and special function. Currently, the alga Haematococcus pluvialis (alternative name H. lacustris) has been considered as one of the best large-scale producers of natural AXT.
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