The two main drugs used in the treatment of gastro-oesophageal reflux disease are proton pump inhibitors and histamine-2 receptor antagonists and both these agents have been implicated in a number of adverse effects, leading to considerable controversies related to their long-term use. This paper is aimed at a critical review of the published literature and the clinical significance of these reported side effects, most of which are associations rather than causal.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8666855 | PMC |
| http://dx.doi.org/10.1136/flgastro-2019-101386 | DOI Listing |
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