A Pd-catalyzed atroposelective C-H allylation with 1,1-disubstituted alkenes was developed for the synthesis of enantioenriched -aryl peptoid atropisomers via β-H elimination using commercially available and inexpensive L-Glu-OH as a chiral ligand. Exclusive allylic selectivity was achieved. Additionally, a series of enantioenriched -aryl peptoid atropisomers were obtained in synthetically useful yields with excellent enantioselectivities (up to 90% yield and 97% ee).
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