Symmetry Reduction in a Hyperpolarization-Activated Homotetrameric Ion Channel.

Biochemistry

Department of Biochemistry and Biophysics, University of California San Francisco, Genentech Hall, 600 16th Street, San Francisco, California 94158, United States.

Published: October 2022

Plants obtain nutrients from the soil via transmembrane transporters and channels in their root hairs, from which ions radially transport in toward the xylem for distribution across the plant body. We determined structures of the hyperpolarization-activated channel AKT1 from , which mediates K uptake from the soil into plant roots. These structures of AtAKT1 embedded in lipid nanodiscs show that the channel undergoes a reduction of C4 to C2 symmetry, possibly to regulate its electrical activation.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9931035PMC
http://dx.doi.org/10.1021/acs.biochem.1c00654DOI Listing

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