AI Article Synopsis
- Two new compounds, 9,11-dihydrogracilin A and 9,11-dihydrogracillinone A, were discovered in the sponge Dendrilla antarctica, which was collected at a depth of 49 m near Tierra del Fuego.
- The sponge's lack of epibionts and the abundance of these compounds led researchers to include them in paints designed to prevent marine fouling.
- Tests showed that both compounds effectively inhibited the growth of various marine organisms, suggesting their potential as natural antifouling agents.
Article Abstract
Two nor-diterpenes, 9,11-dihydrogracilin A (1) and the previously unreported 9,11-dihydrogracillinone A (2), were isolated from the sponge Dendrilla antarctica. The sponge was collected by trawling at a depth of 49 m, from the research vessel Puerto Deseado, near the coast of Tierra del Fuego, farther north than the reported habitat for this species. Since these compounds were particularly abundant and the sponge was free from epibionts, both 1 and 2 were included in soluble-matrix paints and tested for antifouling activity in the ocean. The results obtained from these experiments clearly indicated a potent antifouling activity for both compounds against a variety of colonizing organisms, and established a probable role as natural antifoulants for these abundant secondary metabolites and other structurally related compounds previously isolated from Dendrilla spp.
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Article Synopsis
- Two new compounds, 9,11-dihydrogracilin A and 9,11-dihydrogracillinone A, were discovered in the sponge Dendrilla antarctica, which was collected at a depth of 49 m near Tierra del Fuego.
- The sponge's lack of epibionts and the abundance of these compounds led researchers to include them in paints designed to prevent marine fouling.
- Tests showed that both compounds effectively inhibited the growth of various marine organisms, suggesting their potential as natural antifouling agents.
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7-Hydroxyneolamellarin A (7-OH-Neo A, 1), a natural marine product derived from sponge Dendrilla nigra, was first synthesized with 10% overall yield under the instruction of convergent synthetic strategy. We found that 7-OH-Neo A could attenuate the accumulation of hypoxia-inducible factor-1α (HIF-1α) protein and inhibit vascular epidermal growth factor (VEGF) transcriptional activity, showing well inhibitory effect on HIF-1 signaling pathway. Meantime, 7-OH-Neo A had the well anti-tumor activities, such as inhibiting tumor angiogenesis, proliferation, migration and invasion.
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