A 3-year-old spayed female Siberian Husky presented for evaluation following ingestion of approximately 429 mg/kg of lamotrigine extended-release. She demonstrated severe neurologic and cardiac signs and was treated with lipid emulsion, anticonvulsants, antiarrhythmics and aggressive decontamination and supportive care. She was successfully discharged from the hospital 5 days later.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8677885PMC
http://dx.doi.org/10.1002/ccr3.5169DOI Listing

Publication Analysis

Top Keywords

lamotrigine extended-release
8
successful management
4
management massive
4
massive lamotrigine
4
extended-release intoxication
4
intoxication dog
4
dog 3-year-old
4
3-year-old spayed
4
spayed female
4
female siberian
4

Similar Publications

Objective: We aimed to investigate the ambiguous findings of earlier research regarding the reduction of quetiapine plasma levels when combined with lamotrigine, most likely via UDP-glucuronosyltransferase induction by lamotrigine.

Methods: One thousand one hundred and fifty samples, divided into four groups of patients receiving either quetiapine immediate- (IR) or extended-release (XR) without or in combination with lamotrigine were compared regarding absolute and dose-adjusted plasma concentrations. Furthermore, samples of intra-individual controls were analyzed.

View Article and Find Full Text PDF

Purpose: Lamotrigine was previously reported to reduce serum concentration of quetiapine. The aim of this study was to investigate whether lamotrigine dose or quetiapine formulation was of importance for the drug interaction.

Methods: Patients combining lamotrigine with quetiapine (cases) were included retrospectively from a routine therapeutic drug monitoring (TDM) service, as were a control group of patients using quetiapine without any interacting drugs.

View Article and Find Full Text PDF

Quantitative determination of related substances for Lamotrigine extended release tablet by RP-HPLC.

Heliyon

May 2023

Vishwakarma University, VU School of Pharmacy, Department of Pharmaceutical Chemistry & Analysis, Pune, 411048 Maharashtra, India.

Article Synopsis
  • Lamotrigine extended release (LAMICTAL XR) is an anticonvulsant used to treat various types of seizures, including generalized tonic-clonic and partial seizures.
  • The study aims to develop a reliable RP-HPLC analytical method for measuring related substances in LAMICTAL XR, ensuring it is straightforward, sensitive, and validated according to ICH guidelines.
  • The method showed excellent linearity and accuracy, making it suitable for quality control and stability studies in pharmaceutical applications.
View Article and Find Full Text PDF

Generic lamotrigine extended-release tablets are bioequivalent to innovator drug in fully replicated crossover bioequivalence study.

Epilepsia

January 2023

Office of Research and Standards, Office of Generic Drugs, Center for Drug Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, Maryland, USA.

Objective: Lamotrigine is a commonly prescribed antiepileptic drug. U.S.

View Article and Find Full Text PDF

Should patients skip late doses of medication? A pharmacokinetic perspective.

J Pharmacokinet Pharmacodyn

August 2022

Department of Mathematics, University of Utah, Salt Lake City, UT, 84112, USA.

Missed doses, late doses, and other dosing irregularities are major barriers to effective pharmacotherapy, especially for the treatment of chronic conditions. What should a patient do if they did not take their last dose at the prescribed time? Should they take it late or skip it? In this paper, we investigate the pharmacokinetic effects of taking a late dose. We consider a single compartment model with linear absorption and elimination for a patient instructed to take doses at regular time intervals.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!