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Early Experience of High-dose Intravenous in Critically Ill Patients of COVID-19. | LitMetric

AI Article Synopsis

  • Immune dysregulation is a major issue in COVID-19, and Mycobacterium w (Mw) has shown effectiveness against it, particularly when administered intravenously (IV) to critically ill patients.* -
  • In a case analysis of six COVID-19 patients, those treated with 0.6 mL of Mw via IV showed improved oxygen requirements and significant drops in inflammatory markers without any side effects.* -
  • The findings suggest that IV administration of Mw could be a beneficial treatment in critically ill COVID-19 patients, warranting further exploration into this method.*

Article Abstract

Background: Immune dysregulation is one of the main reasons for mortality and morbidity in coronavirus disease 2019 (COVID-19). Mycobacterium w (Mw) is recently approved for gram-negative sepsis. Moreover, it is also found effective in COVID-19 patients in previous studies. The traditional route of administration for Mw is intradermal, which has a limitation of administering 0.1 mL per injection and local injection site reaction. Intravenous (IV) administration of Mw has not been explored in COVID-19. We report the retrospective analysis of six critically ill COVID-19 patients who received Mw (IV).

Patients And Methods: At baseline, all patients in this case series required O supplementation, and their inflammatory biomarkers were elevated. All patients received 0.6 mL Mw (high-dose) in normal saline along with the standard-of-care treatment.

Results: After Mw administration, gradual improvement in O requirement was observed and patients were discharged from the hospital with no mortality. A reduction in mean C-reactive protein (CRP) (51.48-18.52 mg/dL), interleukin-6 (IL-6) (260.22-14.47 pg/mL), and FiO (81.67-43.33) was also observed. No side effects were observed with the use of Mw by IV route.

Conclusion: Use of 0.6 mL Mw by IV route in this case series was associated with decreased O supplementation without any side effects in critically ill patients of COVID-19.

How To Cite This Article: Patel PS, Patel S, Shah V, Aswani V, Narwaria M. Early Experience of High-dose Intravenous in Critically Ill Patients of COVID-19. Indian J Crit Care Med 2021;25(9):1066-1068.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8664032PMC
http://dx.doi.org/10.5005/jp-journals-10071-23963DOI Listing

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