Two new -lignans siamensinols A-B (-) and seven known compounds agatharesinol (), syringaresinol-glucoside (), noreugenin (), 8-methyleugenitol (), melachromone (), uncinoside A () and daucosterol () were isolated from Hieron. The structures of the new compounds were elucidated on the basis of comprehensive spectroscopic methods, including 1 D, 2 D-NMR, HR-ESI-MS and CD spectrometry. Compounds showed moderate inhibitory effect on MOLT-3 cells while 8-methyleugenitol () exhibited moderate inhibitory effect on three tumor cells (HepG2, A549 and HuCCA-1). Compounds showed the potent cancer chemoprevention in DPPH, XXO, IXO and AIA assays.
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| http://dx.doi.org/10.1080/14786419.2021.2022664 | DOI Listing |
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Two new -lignans, siamensinols A and B, from Hieron. and their biological activities.
Nat Prod Res
November 2022
Laboratory of Medicinal Chemistry, Chulabhorn Research Institute, Laksi, Bangkok, Thailand.
Two new -lignans siamensinols A-B (-) and seven known compounds agatharesinol (), syringaresinol-glucoside (), noreugenin (), 8-methyleugenitol (), melachromone (), uncinoside A () and daucosterol () were isolated from Hieron. The structures of the new compounds were elucidated on the basis of comprehensive spectroscopic methods, including 1 D, 2 D-NMR, HR-ESI-MS and CD spectrometry. Compounds showed moderate inhibitory effect on MOLT-3 cells while 8-methyleugenitol () exhibited moderate inhibitory effect on three tumor cells (HepG2, A549 and HuCCA-1).
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