Photophysical Properties of Linked Zinc Phthalocyanine to Acryloyl Chloride:-vinylpyrrolidone Copolymer.

This paper focuses on the linking of zinc phthalocyanine (ZnPc) to -vinylpyrrolidone (-VP): acryloyl chloride (ClAC) copolymer. The synthesis of binary -VP:ClAC copolymer was performed by the radical polymerization method and then grafted to ZnPc by the Friedel Crafts acylation reaction. We have developed a water-soluble ZnPc:ClAC:-VP photosensitizer with a narrow absorption band at 970 nm, fluorescence at λ = 825 nm and the decay fluorescence profile with 3-decay relatively longer times of 1.2 µs, 4.6 µs, and 37 µs. The concentration-dependent dark cytotoxicity investigated in normal fibroblasts (NHDF), malignant melanoma (MeWo), adenocarcinoma (HeLa), and hepatocellular carcinoma (HepG2) cell lines incubated to increased concentrations of ZnPc:ClAC:-VP (up to 40 μM) for 24 h in the dark show low cytotoxicity. Maximum cell viability in HeLa and HepG2 tumor cell lines was observed.