Recent Advances in Aptasensor for Cytokine Detection: A Review.

Sensors (Basel)

Department of Chemical Engineering, Kwangwoon University, 20 Kwangwoon-Ro, Nowon-gu, Seoul 01897, Korea.

Published: December 2021

AI Article Synopsis

  • Cytokines are immune cell proteins that facilitate communication and regulate processes like cell growth and recovery, but too much cytokine secretion can lead to harmful inflammation.
  • Monitoring cytokine levels in living organisms is crucial for advancing medical and biological research.
  • Recent studies focus on detecting cytokines using aptasensors, which utilize aptamers—single-stranded nucleic acids that mimic antibodies and offer advantages like easy production and modification.

Article Abstract

Cytokines are proteins secreted by immune cells. They promote cell signal transduction and are involved in cell replication, death, and recovery. Cytokines are immune modulators, but their excessive secretion causes uncontrolled inflammation that attacks normal cells. Considering the properties of cytokines, monitoring the secretion of cytokines in vivo is of great value for medical and biological research. In this review, we offer a report on recent studies for cytokine detection, especially studies on aptasensors using aptamers. Aptamers are single strand nucleic acids that form a stable three-dimensional structure and have been receiving attention due to various characteristics such as simple production methods, low molecular weight, and ease of modification while performing a physiological role similar to antibodies.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8705356PMC
http://dx.doi.org/10.3390/s21248491DOI Listing

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