Higher mass-normalized net energy cost of walking (NetC) and mechanical pendular recovery are observed in obese compared to lean adults. This study aimed to investigate the effect of different classes of obesity on the energetics and mechanics of walking and to explore the relationships between body mass, NetC and gait mechanics by using principal component analysis (PCA). NetC and gait mechanics were computed in severely obese (SOG; = 18, BMI = 40.1 ± 4.4 kg·m), moderately obese (MOG; = 17, BMI = 32.2 ± 1.5 kg·m) and normal-weight (NWG; = 13, BMI = 22.0 ± 1.5 kg·m) adults during five walking trials (0.56, 0.83, 1.11, 1.39, 1.67 m·s) on an instrumented treadmill. NetC was significantly higher in SOG compared to NWG ( = 0.019), with no significant difference between SOG and MOG ( = 0.14), nor between MOG and NWG ( = 0.27). Recovery was significantly higher in SOG than in NWG ( = 0.028), with no significant difference between SOG and MOG ( = 0.13), nor between MOG and NWG ( = 0.35). PCA models explained between 17.0% and 44.2% of the data variance. This study showed that: (1) obesity class influences the gait energetics and mechanics; (2) PCA was able to identify two components, showing that the obesity class is associated with lower walking efficiency and better pendulum-like characteristics.
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http://dx.doi.org/10.3390/nu13124546 | DOI Listing |
Eur J Case Rep Intern Med
December 2024
Internal Medicine, Holy Family Hospital, Rawalpindi, Pakistan.
Background: Andersen-Tawil syndrome (ATS) is a rare autosomal dominant disorder caused by variants in the gene. It is associated with periodic paralysis, dysmorphic features and cardiac arrhythmias. The syndrome exhibits incomplete penetrance, leading to a broad spectrum of clinical manifestations, making diagnosis challenging.
View Article and Find Full Text PDFPhytother Res
January 2025
Faculty of Pharmaceutical Science, Assam Down Town University, Guwahati, Assam, India.
Metabolic syndrome (MetS) is a cluster of interrelated metabolic abnormalities that significantly elevate the risk of cardiovascular disease, obesity, and diabetes. Flavonoids, a diverse class of bioactive polyphenolic compounds found in plant-derived foods and beverages, have garnered increasing attention as potential therapeutic agents for improving metabolic health. This review provides a comprehensive analysis of the therapeutic effects of flavonoids in the context of the MetS, with a particular focus on their modulation of the AMP-activated protein kinase (AMPK) pathway.
View Article and Find Full Text PDFEur J Pediatr
January 2025
Faculty of Health Sciences, Department of Clinical Research, University of Southern Denmark, Odense, Denmark.
Unlabelled: This study aimed to estimate the effects of an intensive school-based physical education intervention on the risk of developing overweight or obesity in primary school students when accounting for the moderating role of socioeconomic status. This quasi-experimental trial included data from primary school students participating in an intensive physical education program comprising 4.5 h of weekly physical activity compared to 1.
View Article and Find Full Text PDFIntroduction: Obesity is a worldwide epidemic, with up to 17% of French population affected. European guidelines recommend surgical management at specific weight and comorbidity level; however, less than 2% of eligible patients undergo surgical bariatric interventions. To extend the benefits of bariatric interventions to the untreated population with obesity, endoscopic techniques such as endoscopic sleeve gastroplasty (ESG) have been developed.
View Article and Find Full Text PDFAm J Obstet Gynecol MFM
January 2025
School of Medicine, Tufts University; Tufts Medical Center.
Objective: The maternal metabolic environment in early pregnancy can influence fetal growth trajectories. Our objective was to identify interventions initiated in early pregnancy (<20 weeks gestation) in pregnant individuals with risk factors for hyperglycemia and report their impact on primary (neonatal adiposity, small for gestational age, large for gestational age, macrosomia) and secondary outcomes (gestational weight gain, maternal hypertensive disorder, birth injury, NICU admission, preterm delivery, emergency cesarean section).
Data Sources: We searched Cochrane Central database, Medline, Embase, CINAHL databases, and clinicaltrials.
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