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Intraventricular baclofen for the treatment of pediatric spasticity in cerebral palsy: technique and outcomes.
J Neurosurg Pediatr
January 2025
Departments of1Neurosurgery and.
Objective: Intraventricular baclofen (IVB) administration is used for the treatment of secondary dystonia associated with cerebral palsy (CP), but it has not been reported as a first-line infusion technique for spasticity. In this study, the authors report outcomes of patients with mixed or isolated spasticity treated with IVB administration.
Methods: A retrospective analysis was performed of consecutive patients treated with IVB between 2019 and 2023.
A Combined Comprehensive Palliative and Rehabilitative Care Plan for a Child With Cerebral Palsy.
Cureus
December 2024
Physical Medicine and Rehabilitation, All India Institute of Medical Sciences, New Delhi, New Delhi, IND.
Cerebral palsy (CP) is a group of neurological disorders that affect movement, muscle tone, and motor skills. Here, we present a case of an 11-year-old female patient who presented with tightness in both lower limbs, since birth, and delayed walking, accompanied by difficulty walking due to spasticity. She was diagnosed with spastic diplegic cerebral palsy.
View Article and Find Full Text PDFVoltage-sensitive calcium channels contribute to depolarization of both motor- and interneurons in animal studies, but less is known of their contribution to human motor control and whether blocking them has potential in future antispasmodic treatment in humans. Therefore, this study investigated the acute effect of Nimodipine on the transmission of human spinal reflex pathways involved in spasticity. In a double-blinded, cross-over study, we measured soleus muscle stretch- and H-reflexes, and tibialis anterior cutaneous reflexes in nineteen healthy subjects before and after Nimodipine (tab-let 60mg) or Baclofen (tablet 25mg).
View Article and Find Full Text PDFEfficacy of multimodal treatment involving Baclofen, pelvic floor physiotherapy and polysomnography for sleep related painful erections (SRPE): a single centre observational cohort study.
Int J Impot Res
December 2024
Guy's and St Thomas' NHS Foundation Trust, London, UK.
Article Synopsis
- Sleep Related Painful Erections (SRPE) are REM sleep parasomnias that can severely affect sleep quality and daily functioning, prompting the development of a specialized diagnostic and treatment pathway.
- Diagnostic measures included a thorough review of patient history, clinical examinations, and various tests to identify other causes of penile pain, leading to a structured approach that involved medications, sleep studies, and pelvic floor therapy.
- Out of 20 patients treated, 70.6% experienced symptom relief, with significant improvements seen in sleep quality and pelvic floor assessments, highlighting the effectiveness of this comprehensive management plan.
Modern pharmacotherapy guidance for treating alcohol use disorders.
Expert Opin Pharmacother
December 2024
Forel Clinic, Addiction Treatment Center, Switzerland.
Introduction: Alcohol use disorder (AUD) is prevalent and recognized as a chronic, relapsing disorder. Even though effective treatment options are available, AUD is strongly undertreated. As adjuvant treatment strategies accompanying psychosocial treatments, pharmacological strategies can increase the efficacy of AUD treatment options.
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