The seasonal activity of peptic gastroduodenal ulcers was studied on the basis of 17,106 gastroduodenoscopies which were done during a 10 years period. The activity of gastric and duodenal ulcer was increased only in autumn; their number in spring did not deviate from the average. The frequency of bleeding in duodenal ulcers was increased in autumn, whereas the gastric ulcer-bleeding was detected in more patients during winter. According to this examination the regular spring-autumn periodicity is not typical for the peptic ulcer.
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