Vδ2 γδT cells are unconventional T cells that can be activated by cytokines without TCR signaling. Adenovirus vaccine vectors activated Vδ2 γδT cells in an interleukin 18-, TNF-, and type I interferon-dependent manner. This stimulatory capacity was associated with adenovirus vectors of non-species C origin, including the ChAdOx1 vaccine platform.

Download full-text PDF

Source
http://dx.doi.org/10.1002/eji.202149367DOI Listing

Publication Analysis

Top Keywords

vδ2 γδt
12
γδt cells
12
adenovirus vectors
8
vectors activate
4
activate vδ2
4
cells
4
cells type
4
type interferon-
4
interferon- tnf-
4
tnf- il-18-dependent
4

Similar Publications

Family socioeconomic status and the parent-child relationship in Chinese adolescents: the multiple serial mediating roles of visual art activities.

BMC Public Health

May 2022

Faculty of Education, Southwest University, Educational Leadership and Management, No.2 Tiansheng Road, Beibei District, Chongqing, 400715, PR China.

Background: In light of the recent policy reform in China, the present study aims to investigate the potential impact of family SES on the quality of the parent-child relationship (PCR) through the serial mediating role of participation in organized visual art activities in privately owned centers (VAA1) and parent-supervised visual art activities (VAA2) across genders.

Method: A cross-sectional study was conducted in anonymous province located in the southwestern part of China. A total of 1624 primary school students aged 7 to 14 years were recruited through a random sampling technique.

View Article and Find Full Text PDF

Modulating activity of mistletoe lectins 1 and 2 on the lymphatic system in BALB/c-mice.

Phytomedicine

January 1996

Institute of Medicinal Microbiology and Hygiene, University of Cologne, D-50935 Cologne, Goldenfelsstr. 19-21.

The galactoside-specific lectin (mistletoe lectin-1, VAA-1) and the N-acetylgalactosamine-specific lectin (mistletoe lectin-2, VAA-2) were purified from aqueous mistletoe extract and checked for their immunoactive potency. Regular subcutaneous administration of the optimal immunomodulating VAA-1 /VAA-2 dosage (1 ng lectin/kg body weight) could be shown to modulate thymocyte proliferation, maturation, emigration and activation in BALB/c-mice. Thus, the increase in thymocyte counts was statistically significant after VAA-1 treatment.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!