AI Article Synopsis
- A systematic review and meta-analysis was conducted to assess the clinical characteristics and prognosis of non-Hodgkin's lymphoma (NHL) patients infected with chronic hepatitis B virus (HBV).
- The study analyzed 23 retrospective studies involving over 1200 HBsAg+ NHL patients, revealing a poorer overall and progression-free survival compared to HBsAg- patients, along with a higher likelihood of chemotherapy-induced liver issues.
- Key findings indicated that HBsAg+ patients tend to be younger, have more advanced disease, and present with unique symptoms such as B symptoms and organ involvement, particularly in diffuse large B-cell lymphoma (DLBCL) cases.
Article Abstract
Objectives: No clear consensus has been reached about the clinical features in hepatitis B virus (HBV)-associated non-Hodgkin's lymphoma (NHL) patients. We performed a systematic review and meta-analysis to explore the clinical characteristics and prognosis of NHL patients with chronic HBV infection (HBsAg+).
Methods: Seven electronic databases were searched for relevant studies up to 31 January 2021. Hazard ratio (HR) or odds ratio (OR) corresponding to 95% confidence interval (CI) were calculated to estimate the outcomes. The primary outcome was survival outcome, including overall survival (OS) and progression-free survival (PFS). Subgroup analysis was performed in diffuse large B-cell lymphoma (DLBCL) patients.
Results: Twenty-three retrospective studies, comprising of 1202 HBsAg+ NHL patients and 4448 HBsAg- NHL patients, were included. Twenty-two studies were conducted on Chinese patients. Compared with HBsAg- NHL patients, significantly shorter OS (HR 1.68; 95% CI 1.48-1.91) and PFS (HR 1.80; 95% CI 1.20-2.71), lower rate of complete remission (OR 0.59, 95% CI 0.44-0.80) and higher frequency of hepatic dysfunction during chemotherapy (OR 3.46; 95% CI 2.61-4.57) were demonstrated in HBsAg+ NHL patients. Moreover, HBsAg+ patients were characterized by a younger age of disease onset, advanced disease stage, higher level of LDH and more frequent presence of B symptoms, and involvement of spleen and liver at diagnosis. Furthermore, subgroup analysis in DLBCL patients was also showed similar results.
Conclusion: Our study implicated that NHL patients, especially DLBCL, with chronic HBV infection displayed inferior prognosis, higher incidence of hepatic dysfunction during chemotherapy and distinct clinical features.
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| http://dx.doi.org/10.1080/16078454.2021.2011546 | DOI Listing |
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