AI Article Synopsis
- This study explored the role of PD-1 CXCR5 follicular helper CD8 T cells in kidney transplant recipients to understand their association with renal allograft dysfunction.
- It involved 82 kidney transplant recipients, separating them into chronic allograft dysfunction (CAD) and stable groups, and examined specific T cell populations using flow cytometry.
- Findings indicated that increased levels of PD-1 CXCR5 CD8 T cells correlated with renal dysfunction and suggested their potential as biomarkers for identifying issues related to kidney transplant rejection.
Article Abstract
Background: The roles of PD-1 CXCR5 follicular helper CD8 T cell were reported in different disease conditions, but their roles in transplantation are unclear. In this study, the association between PD-1 CXCR5 follicular helper CD8 T cell and renal allograft dysfunction in kidney transplant recipients (KTRs) was investigated.
Methods: 82 KTRs were enrolled in this study. 45 KTRs were included in the chronic allograft dysfunction (CAD) group, and 37 KTRs were included in the stable recipients group. Among the CAD group, 12 cases of antibody-mediated rejection (ABMR) and 4 cases of T cell-mediated rejection (TCMR) were diagnosed by biopsy. The percentage of CXCR5 CD8 T cells and the co-expression of signal transducers and activators of transcription 4 (STAT4), STAT5, and PD-1 in peripheral blood were determined by flow cytometry.
Results: The expression of CXCR5 on CD3 CD8 T cells and the percentage of STAT5 CXCR5 cells in the CD3 CD8 T-cell population were significantly lower in the CAD group (p < 0.05), while the expression of PD-1 CXCR5 CD8 T cells was significantly higher (p < 0.05). Through logistic regression analysis, we concluded that the percentage of PD-1 CXCR5 CD8 T cells was an independent risk factor for renal dysfunction. Grouping by pathological type, PD-1 CXCR5 CD8 T cells showed relatively good diagnostic efficacy for ABMR by ROC analysis.
Conclusions: Our results suggested that PD-1 CXCR5 CD8 T cells were a promising biomarker for distinguishing renal allograft dysfunction and different allograft pathological types. Also, our findings may provide new ways of identifying and treating allograft rejection.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8842189 | PMC |
| http://dx.doi.org/10.1002/jcla.24200 | DOI Listing |
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