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Moderate alcohol consumption and lipoprotein subfractions: a systematic review of intervention and observational studies. | LitMetric
Context : Moderate alcohol consumption is associated with decreased risk of cardiovascular disease (CVD) and improvement in cardiovascular risk markers, including lipoproteins and lipoprotein subfractions.Objective : To systematically review the relationship between moderate alcohol intake, lipoprotein subfractions, and related mechanisms.Data Sources : Following PRISMA, all human and ex vivo studies with an alcohol intake up to 60 g/d were included from 8 databases.Data Extraction : A total of 17 478 studies were screened, and data were extracted from 37 intervention and 77 observational studies.Results : Alcohol intake was positively associated with all HDL subfractions. A few studies found lower levels of small LDLs, increased average LDL particle size, and nonlinear relationships to apolipoprotein B-containing lipoproteins. Cholesterol efflux capacity and paraoxonase activity were consistently increased. Several studies had unclear or high risk of bias, and heterogeneous laboratory methods restricted comparability between studies.Conclusions : Up to 60 g/d alcohol can cause changes in lipoprotein subfractions and related mechanisms that could influence cardiovascular health.Systematic Review Registration : PROSPERO registration no. 98955.
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