Aims: is used in Beninese folk medicine for treatment of gastroenteritis. This study aims to compare the antimicrobial, antioxidant, and anti-inflammatory activity of the hydroalcoholic extracts of the leaves, trunk bark, and root.
Materials And Methods: The antimicrobial activity was evaluated by the broth microdilution method on 06 bacterial strains including 03 wild-type strains ( 0157H, sp., and sp.) and 03 reference strains ( ATCC 25922, ATCC 29213, and ATCC 27853), whereas the anti-inflammatory activity was performed by the carrageenan-induced paw edema method on rats. The DPPH-free radical scavenging was used to determine the antioxidant activity.
Results: The MICs of the leaf extracts varied from 6.25 to 25 mg/mL for all strains. The MICs of the stem bark extracts were 6.5 to 25 g/mL for five strains ( 0157H, ATCC 25922, sp., ATCC 25922, and ATCC 27853) and 3.125 mg/mL for . Concerning the root extracts, the MICs varied from 12.5 to 50 mg/mL. The best anti-inflammatory power was obtained with the stem bark extract with the percentages of inhibition of 36.09%, 38.98%, and 39.50%. The DPPH test showed that the hydroethanolic extract of the 03 parts of has a moderate antiradical power compared to the control which was quercetin.
Conclusion: In view of the different pharmacological activity recorded, the extract of the leaves should be recommended to treat patients suffering from gastroenteriditis.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8709746 | PMC |
| http://dx.doi.org/10.1155/2021/8938534 | DOI Listing |
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