AI Article Synopsis
- - This study focuses on finding an effective treatment for a tough respiratory pathogen that is resistant to many drugs, comparing it to other non-tuberculous mycobacteria (NTM).
- - Researchers tested various drugs alongside clarithromycin and discovered that omadacycline worked best in combination, showing strong positive synergy against the pathogen.
- - The effectiveness of the clarithromycin-omadacycline treatment was validated using a zebrafish model, where it not only inhibited the spread of the infection but also significantly improved the lifespan of the infected fish.
Article Abstract
is a difficult respiratory pathogen to treat, when compared to other nontuberculus mycobacteria (NTM), due to its drug resistance. In this study, we aimed to find a new clarithromycin partner that potentiated strong, positive, synergy against among current anti- drugs, including omadacycline, amikacin, rifabutin, bedaquiline, and cefoxitine. First, we determined the minimum inhibitory concentrations required of all the drugs tested for subsp. CIP104536 treatment using a resazurin microplate assay. Next, the best synergistic partner for clarithromycin against was determined using an checkerboard combination assay. Among the drug combinations evaluated, omadacycline showed the best synergistic effect with clarithromycin, with a fractional inhibitory concentration index of 0.4. This positive effect was also observed against clinical isolates and anti- drug resistant strains. Lastly, this combination was further validated using a infected zebrafish model. In this model, the clarithromycin-omadacyline regimen was found to inhibit the dissemination of and it significantly extended the lifespan of the infected zebrafish. In summation, the synergy between two anti- compounds, clarithromycin and omadacycline, provides an attractive foundation for a new treatment regimen.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8693020 | PMC |
| http://dx.doi.org/10.3389/fphar.2021.790767 | DOI Listing |
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