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Mitochondrial bioenergetic dysfunction linked to myxomatous mitral valve degeneration explored by PBMCs metabolism analysis.
Biochim Biophys Acta Bioenerg
November 2024
Dep. of Veterinary Medical Sciences, University of Bologna, Ozzano Emilia, Italy. Electronic address:
Impaired mitochondria cause an impressive decrease in ATP production becoming a common condition of cardiovascular diseases. Myxomatous mitral valve disease (MMVD) is characterized by mitochondrial dysfunction. By a non-invasive procedure of metabolism analysis on peripheral blood mononuclear cells, we exploit ex-vivo studies that directly constitute a translational approach to evaluate the cell bioenergetics.
View Article and Find Full Text PDFA deep dive into the percutaneous mitral valve data.
Curr Opin Cardiol
May 2024
Department of Cardiovascular Surgery, Mount Sinai Health System, New York, New York, USA.
Purpose Of Review: This review offers insights into percutaneous mitral valve management, emphasizing pivotal trials that contributed to its evolution.
Recent Findings: Mitral regurgitation (MR) is a highly prevalent heart valve disease, with surgical intervention being the gold standard for managing primary MR. However, a notable proportion of patients face ineligibility criteria or are at high surgical risk, particularly in the setting of secondary MR.
Chordal Preservation Mitral Valve Replacement for Delayed MitraClip Failure.
Tex Heart Inst J
November 2022
Department of Cardiovascular Disease, Mayo Clinic, Rochester, Minnesota.
Mitral valve replacement may be indicated in delayed MitraClip (Abbott) failure. Although it would be best to preserve the chordal apparatus during surgical mitral valve replacement, this has not been reported for delayed MitraClip failure, probably because there is almost always impressive inflammation around the MitraClip, which has likely precluded previous attempts at chordal preservation. A successful surgical chordal preservation mitral valve replacement in delayed MitraClip failure is reported here.
View Article and Find Full Text PDFTranscatheter mitral valve repair in a liver transplant candidate.
Echocardiography
December 2022
Department of Cardiology, MD Anderson Cancer Center, University of Texas, Houston, Texas, USA.
Untreated severe mitral regurgitation (MR) is associated with poor outcomes due to the adverse consequences of long-standing volume overload on the left ventricle and left atrium, which leads to pulmonary hypertension and right-sided heart failure. Early intervention results in favorable long-term outcomes making appropriate timing of intervention very critical. We present a 53-year-old male with severe symptomatic MR and right sided-heart failure which progressed to cardiac cirrhosis necessitating enrollment to the liver transplant list.
View Article and Find Full Text PDFImpressive Mitral Valve Aneurysm Following Thickening of the Anterior Leaflet.
Circ J
May 2022
Department of Cardiovascular Medicine, Yoshinogawa Medical Center.
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