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Diarylheptanoid glycosides from Zingiber officinale peel and their anti-apoptotic activity. | LitMetric

AI Article Synopsis

  • Four new diarylheptanoid glycosides were identified from Zingiber officinale peel, specifically compounds 1-4, with complex chemical structures.
  • The structures were confirmed using advanced techniques like high-resolution electrospray ionization mass spectrometry (HR-ESI-MS) and various types of nuclear magnetic resonance (NMR) spectroscopy.
  • These compounds demonstrated significant protective effects on human lung bronchial epithelial cells against damage induced by lipopolysaccharide (LPS), enhancing cell survival at a concentration of 10 μM.

Article Abstract

Four new diarylheptanoid glycosides (1-4), (1S,3R,5S)-2-(4-hydroxy-3- methoxyphenyl)-6-[2-(4-hydroxyphenyl)ethyl]-tetrahydropyran-4-ol-4'-O-β-D-glucopyranoside (1), (1S,3R,5S)-2-(4,5-dihydroxy-3-methoxyphenyl)-6-[2-(4-hydroxyphenyl) ethyl]-tetrahydropyran-4-ol-4'-O-β-D-glucopyranoside (2), (1S,3R,5S)-2-(4-hydroxy- 3,5-dimethoxyphenyl)-6-[2-(4-hydroxy-3-methoxyphenyl)ethyl]-tetrahydropyran-4-ol-4'-O-β-D-glucopyranoside (3), and (1R,3R,5R)-2-(4-hydroxy-3,5-dimethoxyphenyl)- 6-[2-(4-hydroxy-3-methoxyphenyl)ethyl]-tetrahydropyran-4-ol-3-O-β-D-glucopyranoside (4) were isolated from the 50% ethanol extract of Zingiber officinale peel. The structures of the isolated compounds were determined by HR-ESI-MS and extensive spectroscopic techniques (UV, IR, 1D-NMR, and 2D-NMR). Compounds 1-4 significantly increased the survival rate of human normal lung bronchial epithelial cells (BEAS-2B) induced by lipopolysaccharide (LPS) at the concentration of 10 μM.

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Source
http://dx.doi.org/10.1016/j.fitote.2021.105109DOI Listing

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