New discoveries and technologies are driving major advances in our understanding of cancer and underpinning a new era of precision medicine and immunotherapy. However, advances in treatment have been uneven: whereas survival rates for some common cancers are improving rapidly, for others there has been much less progress. In addition, healthcare systems are finding it difficult to provide access to expensive new treatments. There is an urgent need for imaginative policy solutions to incentivise the creation of novel therapies that address the full range of cancer-causing mechanisms. We have worked with organisations across the medical research community to develop consensus statements on how to enhance access to innovative cancer drugs. Here, we present our reflections on these statements.
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| http://dx.doi.org/10.1016/j.drudis.2021.12.015 | DOI Listing |
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A Smart Semi-Implantable Device Integrating Microchannel-Enhanced Sampling and Multiplex Biochemical Testing for Deep Wound Monitoring and Pathogen Identification.
Adv Sci (Weinh)
December 2024
Department of Clinical Laboratory, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.
Monitoring deep wounds is challenging but necessary for high-quality medical treatment. Current methodologies for deep wound monitoring are typically limited to indirect clinical symptoms or costly non-real-time imaging diagnosis. Herein, a smart system is proposed that enables in situ monitoring of deep wounds' status through a semi-implantable device composed of 2 seamlessly connected functional components: 1) the well-designed, microchannel-structured sampling needles that efficiently and conveniently collect samples from deep wound anatomical locations, and 2) the multiplex biochemical testing compartment that facilitates the immediate and persistent detection of multiple biochemical indicators based on a color image processing software accessible to a conventional smartphone.
View Article and Find Full Text PDFBionic Hollow Porous Carbon Nanofibers for Energy-Dense and Rapid Zinc Ion Storage.
Angew Chem Int Ed Engl
December 2024
Nanjing Forestry University, Co-Innovation Center of Efficient Processing and Utilization of Forest Resources, CHINA.
Suboptimal spatial utilization and inefficient access to internal porosity preclude porous carbon cathodes from delivering high energy density in zinc-ion hybrid capacitors (ZIHCs). Inspired by the function of capillaries in biological systems, this study proposes a facile coordination-pyrolysis method to fabricate thin-walled hollow carbon nanofibers (CNFs) with optimized pore structure and surface functional groups for ZHICs. The capillary-like CNFs maximize the electrode/electrolyte interface area, facilitating the optimal utilization of energy storage sites.
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Int Dent J
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King Salman Hospital, Ministry of Health, Riyadh, Saudi Arabia.
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View Article and Find Full Text PDFThe mechanisms of electrical neuromodulation.
J Physiol
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Center for Advancing Neurotechnological Innovation to Application - CRANIA, University Health Network, Toronto, ON, Canada.
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View Article and Find Full Text PDFBrief interventions for chronic pain: Approaches and evidence.
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Department of Anesthesiology, Perioperative and Pain Medicine, Stanford Pain Relief Innovations Lab, Stanford University School of Medicine, 1070 Arastradero Road, Ste. 200, MC5596, Palo Alto, CA, United States. Electronic address:
Various countries have published national guidance supporting the integration of behavioral approaches into chronic pain treatment. Yet multiple barriers prevent broad patient access. Brief treatment formats may address universal shortcomings of therapists and resources and offer patients expanded access to care through lower costs and treatment burdens.
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