The purpose of this article is to describe the regulatory framework of the radiotherapy practice in France.
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| http://dx.doi.org/10.1016/j.canrad.2021.10.003 | DOI Listing |
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Introduction: Although several potential respiratory and cardiovascular health effects of e-cigarettes have been reported, their association with incident cardiometabolic conditions remains unclear.
Methods: We used longitudinal data from the All of Us research program to investigate the association between current exclusive e-cigarette use (EE), exclusive combustible cigarette use (ECC), and dual use (DU) with incident cardiometabolic conditions, including hypertension, type 2 diabetes mellitus (T2DM), chronic obstructive pulmonary disease (COPD), heart failure (HF), and atherosclerotic cardiovascular disease (ASCVD), using Cox regression analyses adjusted for age, sex, race and ethnicity, and body mass index (BMI). ECC use was used as a positive control to validate our methodology/findings.
Acetyl-CoA synthetase (Acs) generates acetyl-coenzyme A (Ac-CoA) but its excessive activity can deplete ATP and lead to a growth arrest. To prevent this, Acs is regulated through Ac-CoA-dependent feedback inhibition executed by Ac-CoA-dependent acetyltransferases such as AcuA in Bacillus subtilis. AcuA acetylates the catalytic lysine of AcsA turning the synthetase inactive.
View Article and Find Full Text PDFTechnical and regulatory challenges in artificial intelligence-based pulse oximetry: a proposed development pipeline.
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Departamento de Ciencia de la Computación, Facultad de Ingeniería, Pontificia Universidad Católica de Chile, Santiago, Chile.
Pulse oximetry, although generally effective under ideal conditions, faces challenges in accurately estimating peripheral oxygen saturation (SpO) in complex clinical scenarios, particularly at lower saturation levels and in patients with darker skin pigmentation. Artificial intelligence (AI) offers the potential to improve SpO monitoring by enabling more accurate, equitable, and accessible estimations. We highlight key challenges in developing AI-enhanced pulse oximetry, including the need for diverse and representative datasets, refined validation protocols addressing ethical concerns such as algorithmic bias, expanded SpO measurement ranges encompassing hypoxaemic levels, and enhanced model interpretability.
View Article and Find Full Text PDFCXCR4-Targeted Ultrasound Microbubbles for Imaging and Enhanced Chemotherapy/Immunotherapy in Liver Cancer.
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Department of Ultrasound, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200092, China. Electronic address:
Ultrasound molecular imaging is an innovative imaging modality that combines ultrasound with molecular probes to observe live biological processes at the cellular and molecular levels. C-X-C chemokine receptor type 4 (CXCR4) is a specific target in liver tumors and plays a crucial role in promoting tumor growth, invasion, metastasis, and angiogenesis. This study pioneered the use of CXCR4-targeted ultrasound molecular imaging for visualized antitumor therapy and investigated the potential of CXCR4-targeted microbubbles (MBs) in sensitizing liver tumor treatment.
View Article and Find Full Text PDFA comprehensive review of neurotransmitter modulation via artificial intelligence: A new frontier in personalized neurobiochemistry.
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Department of Basic Medical Sciences, Khoy University of Medical Sciences, Khoy, Iran. Electronic address:
The deployment of artificial intelligence (AI) is revolutionizing neuropharmacology and drug development, allowing the modulation of neurotransmitter systems at the personal level. This review focuses on the neuropharmacology and regulation of neurotransmitters using predictive modeling, closed-loop neuromodulation, and precision drug design. The fusion of AI with applications such as machine learning, deep-learning, and even computational modeling allows for the real-time tracking and enhancement of biological processes within the body.
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