AI Article Synopsis
- Follicular dendritic cells (FDC) are specialized cells in lymph follicles that retain immune complexes through receptors and are crucial for immune responses.
- The study investigates how different immunoglobulin isotypes and lymphocyte types (B or T cells) affect the transfer of immune complexes to FDC.
- Results show that B cells are more efficient than T cells in transferring immune complexes to FDC, and that certain immunoglobulin isotypes (IgG2a, IgG2b, and IgG1) facilitate this transfer better than others (IgG3 and IgM).
Article Abstract
Follicular dendritic cells (FDC) are located only inside lymph follicles and are characterized mainly by their capacity to retain high amounts of immune complexes by their Fc or C3b receptors. In this work, we examine the influence of immunoglobulin isotypes and the subset of lymphoid cells (B or T) upon the transfer of immune complexes from lymphocytes to FDC. FDC isolated from mice lymph nodes by enzymatic digestion are able to fix, through Fc receptors, gold-labeled immune complexes presented by lymphoid cells. As demonstrated by electron microscopy, this transfer requires the establishment of close contacts between both cell types. Using different cell selection techniques we show that B lymphoid cells take up immune complexes more efficiently than do T lymphoid cells and transfer a larger number of them to FDC. This transfer mechanism is dependent on the immunoglobulin isotype: immune complexes constituted of IgG2a, IgG2b, and IgG1 isotypes are better transferred to FDC than those constituted of IgG3 and IgM.
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| http://dx.doi.org/10.1016/0008-8749(87)90269-3 | DOI Listing |
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