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Accelerating repair of infected bone defects through post-reinforced injectable hydrogel mediated antibacterial/immunoregulatory microenvironment at bone-hydrogel interface.
Carbohydr Polym
March 2025
Department of Orthopedics Trauma and Microsurgery, Zhongnan Hospital, Wuhan University, Wuhan 430000, China; Hubei Clinical Medical Research Center of Trauma and Microsurgery, Wuhan 430000, China. Electronic address:
Functional injectable hydrogel (IH) is promising for infected bone defects (IBDs) repair, but how to endow it with desired antibacterial/immunoregulatory functions as well as avoid mechanical failures during its manipulation has posed as main challenges. Herein, rosmarinic acid (RosA), a natural product with antibacterial/immunoregulatory activities, was utilized to develop a FCR IH through forming phenylboronic acid ester bonds with 4-formylphenyl phenylboronic acid (4-FPBA) grafted chitosan (CS) (FC). After being applied to the IBD site, the FCR IH was then injected with tobramycin (Tob) solution, another alkaline antibacterial drug, to induce in situ crystallization of the FC, endowing the resultant FCRT hydrogel with adaptively enhanced mechanical strength and structural stability.
View Article and Find Full Text PDFA Functional Response in Resource Selection Links Multiscale Responses of a Large Carnivore to Human Mortality Risk.
Ecol Lett
January 2025
School of Natural Resources, University of Nebraska-Lincoln, Lincoln, Nebraska, USA.
Theory suggests that animals make hierarchical, multiscale resource selection decisions to address the hierarchy of factors limiting their fitness. Ecologists have developed tools to link population-level resource selection across scales; yet, theoretical expectations about the relationship between coarse- and fine-scale selection decisions at the individual level remain elusive despite their importance to fitness. With GPS-telemetry data collected across California, USA, we evaluated resource selection of mountain lions (Puma concolor; n = 244) relative to spatial variation in human-caused mortality risk.
View Article and Find Full Text PDFImpact on Quality of Life of Full-Time and Night-Time Braces in Adolescent Idiopathic Scoliosis: A Randomized Clinical Trial.
Spine (Phila Pa 1976)
December 2024
Biomedical Research Institute INCLIVA, Clinic University Hospital, 46010 Valencia, Spain.
Study Design: Randomized clinical trial.
Objective: To compare the effect on quality of life of night-time (NT) and full-time (FT) brace treatment for adolescent idiopathic scoliosis (AIS).
Summary Of Background Data: Conservative treatment of adolescent idiopathic scoliosis (AIS) with full-time (FT) braces has proven to prevent the risk of progression and the need for surgery, with an inversely proportional relationship to the number of hours worn.
"They Think Transgender is Like Something on the Side:" Perceptions of Transgender Women of Color of Cisgender Members of the LGBTQIA+ "Community".
J Homosex
December 2024
Department of Population Health Sciences, College of Medicine, University of Central Florida, Orlando, FL, USA.
Due to multiple minority statuses, transgender women of color are exposed to minority stress through distal (external) stressors from society causing proximal (internal) stress, leading to potentially negative physical and mental health outcomes. Often considered allies to the transgender community, cisgender members of the LGBTQIA+ "community" have historically presented different plights resulting in divergent rights, protections, and societal views. Guided by the minority stress framework, a secondary analysis of individual interviews and focus groups ( = 20) with transgender women of color was performed.
View Article and Find Full Text PDFAllelopathic activity of coffee extracts: implications for germination and initial growth in select weeds and polyploidy in L.
J Toxicol Environ Health A
December 2024
Department of Ecology and Conservation, Federal University of Lavras, Lavras, MG, Brazil.
Coffee beans contain compounds with allelopathic activity, such that some beans that do not meet quality standards might rather be used to obtain a natural herbicide which consequently might be employed to control undesired plants and avoid economic losses. Thus, the objectives of this study were: (1) to investigate the allelopathic effect of different concentrations of green (GC) and roasted (RC) coffee extracts on the inhibition of germination and initial growth of L. L.
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