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Effects of enriched-potassium diet on cardiorespiratory outcomes in experimental non-ischemic chronic heart failure. | LitMetric

AI Article Synopsis

Article Abstract

Background: Chronic heart failure (CHF) is a global health problem. Increased sympathetic outflow, cardiac arrhythmogenesis and irregular breathing patterns have all been associated with poor outcomes in CHF. Several studies showed that activation of the renin-angiotensin system (RAS) play a key role in CHF pathophysiology. Interestingly, potassium (K) supplemented diets showed promising results in normalizing RAS axis and autonomic dysfunction in vascular diseases, lowering cardiovascular risk. Whether subtle increases in dietary K consumption may exert similar effects in CHF has not been previously tested. Accordingly, we aimed to evaluate the effects of dietary K supplementation on cardiorespiratory alterations in rats with CHF.

Methods: Adult male Sprague-Dawley rats underwent volume overload to induce non-ischemic CHF. Animals were randomly allocated to normal chow diet (CHF group) or supplemented K diet (CHF+K group) for 6 weeks. Cardiac arrhythmogenesis, sympathetic outflow, baroreflex sensitivity, breathing disorders, chemoreflex function, respiratory-cardiovascular coupling and cardiac function were evaluated.

Results: Compared to normal chow diet, K supplemented diet in CHF significantly reduced arrhythmia incidence (67.8 ± 15.1 vs. 31.0 ± 3.7 events/hour, CHF vs. CHF+K), decreased cardiac sympathetic tone (ΔHR to propranolol: - 97.4 ± 9.4 vs. - 60.8 ± 8.3 bpm, CHF vs. CHF+K), restored baroreflex function and attenuated irregular breathing patterns. Additionally, supplementation of the diet with K restores normal central respiratory chemoreflex drive and abrogates pathological cardio-respiratory coupling in CHF rats being the outcome an improved cardiac function.

Conclusion: Our findings support that dietary K supplementation in non-ischemic CHF alleviate cardiorespiratory dysfunction.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8710008PMC
http://dx.doi.org/10.1186/s40659-021-00365-zDOI Listing

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