AI Article Synopsis
- The increase in antimicrobial resistance and slow development of new antibiotics have sparked interest in alternative treatments like phage therapy for bacterial infections.
- Although phages have shown promise in individual cases, a definitive demonstration of their effectiveness as a treatment is still lacking due to issues like limited host range and the emergence of phage-resistant bacteria.
- Advances in synthetic biology and genetic engineering could enhance phages' therapeutic abilities, making them safer and more versatile in targeting bacterial pathogens.
Article Abstract
The alarming rise in antimicrobial resistance coupled with a lack of innovation in antibiotics has renewed interest in the development of alternative therapies to combat bacterial infections. Despite phage therapy demonstrating success in various individual cases, a comprehensive and unequivocal demonstration of the therapeutic potential of phages remains to be shown. The co-evolution of phages and their bacterial hosts resulted in several inherent limitations for the use of natural phages as therapeutics such as restricted host range, moderate antibacterial efficacy, and frequent emergence of phage-resistance. However, these constraints can be overcome by leveraging recent advances in synthetic biology and genetic engineering to provide phages with additional therapeutic capabilities, improved safety profiles, and adaptable host ranges. Here, we examine different ways phages can be engineered to deliver heterologous therapeutic payloads to enhance their antibacterial efficacy and discuss their versatile applicability to combat bacterial pathogens.
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| http://dx.doi.org/10.1016/j.coviro.2021.12.003 | DOI Listing |
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