We consider the yielding behavior of amorphous solids under cyclic shear deformation and show that it can be mapped into a random walk in a confining potential with an absorbing boundary. The resulting dynamics is governed by the first passage time into the absorbing state and suffices to capture the essential qualitative features recently observed in atomistic simulations of amorphous solids. Our results provide insight into the mechanism underlying yielding and its robustness. When the possibility of activated escape from absorbing states is added, it leads to a unique determination of a threshold energy and yield strain, suggesting thereby an appealing approach to understanding fatigue failure.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1103/PhysRevLett.127.248002 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Mechanistic Insights into Amorphous Solid Dispersions: Bridging Theory and Practice in Drug Delivery.
Pharm Res
January 2025
Solid State Pharmaceutics Research Laboratory, Department of Pharmaceutical Sciences and Technology, Birla Institute of Technology, Mesra, Ranchi, 835215, Jharkhand, India.
Improving the bioavailability of poorly water-soluble drugs presents a significant challenge in pharmaceutical development. Amorphous solid dispersions (ASDs) have garnered substantial attention for their capability to augment the solubility and dissolution rate of poorly water-soluble drugs, thereby markedly enhancing their bioavailability. ASDs, characterized by a metastable equilibrium where the active pharmaceutical ingredient (API) is molecularly dispersed, offer enhanced absorption compared to crystalline forms.
View Article and Find Full Text PDFLipid core-chitosan shell hybrid nanoparticles for enhanced oral bioavailability of sorafenib.
Int J Biol Macromol
January 2025
College of Pharmacy, Institute of Pharmaceutical Sciences and Technology, Hanyang University ERICA, Ansan 15588, Republic of Korea. Electronic address:
Limited aqueous solubility is a major hurdle resulting in poor and variable oral bioavailability, high doses, side effects, and the suboptimal therapeutic efficacy of sorafenib (SRF). In this study, we developed SRF-loaded solid lipid nanoparticles (SRF-SLNs) and lipid core-chitosan shell hybrid nanoparticles (CS-SRF-SLNs) to improve the oral absorption of SRF. SRF-SLNs were prepared using a stearyl alcohol core stabilized with a surfactant mixture, followed by surface decoration with chitosan to form CS-SRF-SLNs.
View Article and Find Full Text PDFMultiple and transforming vibrational identities of atoms in amorphous solids.
J Chem Phys
January 2025
State Key Laboratory of Nonlinear Mechanics, Institute of Mechanics, Chinese Academy of Sciences, Beijing 100190, China.
Identifying the diverse roles of disorderly packed atoms inside an amorphous solid has been a highly pursued but daunting task in glass physics. By analyzing the full-frequency vibrational modes of a model Cu50Zr50 glass, here, we classify the internal atoms into low-, subhigh-, and high-frequency ones that have different tendencies for rearrangements upon excitations. We find that low-frequency atoms are structurally unfavored and tend to aggregate.
View Article and Find Full Text PDFEvaluation of Drug-Polymer and Drug-Drug Interaction in Cellulosic Multi-Drug Delivery Matrices.
Methods Protoc
January 2025
Department of Pharmacy and Biomedical Sciences, University of Central Lancashire, Preston PR1 2HE, UK.
Multi-drug delivery systems have gained increasing interest from the pharmaceutical industry. Alongside this is the interest in amorphous solid dispersions as an approach to achieve effective oral delivery of compounds with solubility-limited bioavailability. Despite this, there is limited information regarding predicting the behavior of two or more drugs (in amorphous forms) in a polymeric carrier and whether molecular interactions between the compounds, between each compound, and if the polymer have any effect on the physical properties of the system.
View Article and Find Full Text PDFEnhancing Solubility of a BCS Class II Drug- Itraconazole by Developing and Optimizing Solid Lipid Nanoparticles using a Central Composite Design.
Pharm Nanotechnol
January 2025
Department of Pharmaceutical Sciences, Philadelphia College of Pharmacy, Saint Joseph University, Philadelphia, PA.
Background: Itraconazole (ICZ) has been approved by the FDA to treat many fungal infections including, blastomycosis, histoplasmosis, and aspergillosis. ICZ can be also used as prophylaxis in the population who are at high risk for developing systemic fungal infections, such as HIV patients, and chemotherapy patients.
Aim: However, since ICZ is a BCS Class II drug that has low solubility and high permeability, leads to low oral bioavailability.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!