Ameliorative effect of flavonoid-rich extracts from against diabetic cardiomyopathy via serpin A and socs3-a in streptozocin treated rats.

Introduction: The present study access the effect of the flavonoid-rich extract from against cardiomyopathy streptozotocin-induced diabetic rats.

Materials And Methods: The flavonoid-rich extract from leaf (FREGL) was prepared using a standard method. Diabetes was induced by a single intraperitoneal (i.p.) injection of streptozotocin. The experimental animals were divided into five groups as non-diabetic rats, diabetic control, diabetic rats administered low and high doses of FREGL (13 and 26 mg/kg), and metformin-glibenclamide orally for 21 days. Hence, the experimental animals were sacrificed; blood and heart were harvested to determine diverse biochemical parameters, including the gene expressions of serpin A and socs3-a as well as histological examination.

Results: The results demonstrated that FREGL significantly ( < 0.05) reduced fasting blood glucose, total cholesterol, low density lipoprotein (LDL), triglyceride (TG), lipid peroxidation levels, as well as the activities of lactate dehydrogenase and creatine kinase-MB, including the relative gene expressions of serpin A and Socs3-A in diabetic rats. Also, diabetic rats that received different doses of FREGL showed a substantial rise in insulin and high density lipoprotein (HDL) levels, antioxidant enzyme activities, as well as, normal histoarchitecture of the heart tissues.

Conclusion: Therefore, FREGL may be beneficial in alleviating diabetic cardiomyopathy.