Herein we report a new series of bifunctional chelators (BFCs) with high affinity for amyloid β aggregates, strong binding affinity towards Cu(II), and favorable lipophilicity for potential blood-brain barrier (BBB) penetration. The alkyl carboxylate ester pendant arms show high binding affinity towards Cu(II). The BFCs form stable Cu-radiolabeled complexes and exhibit favorable partition coefficient (log ) values of 0.75-0.95. Among the five compounds tested, 64Cu-YW-1 and 64Cu-YW-13 complexes exhibit significant staining of amyloid plaques in autoradiography studies.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8969080 | PMC |
| http://dx.doi.org/10.1039/d1dt02767k | DOI Listing |
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