Two undescribed phenylpropenoid glycosides () and one known analogues () have been isolated and identified from the roots of . The structures of these new compounds were elucidated by extensive spectroscopic analyses (1 D-, 2 D-NMR, HRESIMS, IR, UV) and chemical methods. The anti-inflammatory activities of all isolates were evaluated by measuring their inhibitory effects on PGE production in LPS stimulated RAW 264.7 macrophages.
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http://dx.doi.org/10.1080/14786419.2021.2019736 | DOI Listing |
RSC Adv
July 2022
Institute of Traditional Chinese Medicine & Natural Products, Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, Jinan University Guangzhou 510632 P. R. China +86-20-85221559 +86-20-85221559.
Eight previously unreported phenolic acids (1-8), including three new phenylpropenoid glycosides (1-3), and five undescribed shikimic acid derivatives (4-8), together with six known analogues (9-14), were obtained from the dried leaves of . The structures of these new compounds were elucidated by extensive spectroscopic analyses (1D, 2D-NMR, HRESIMS, IR, UV) and chemical methods. Compounds 1, 2, 4, and 5 were tested for their promotion effect on osteoblastogenesis of pre-osteoblastic MC3T3-E1 cells and inhibitory effect on osteoclastogenesis of RANKL-induced RAW264.
View Article and Find Full Text PDFNat Prod Res
November 2022
China Academy of Chinese Medical Science, Institute of Chinese Materia Medica, Beijing China.
Two undescribed phenylpropenoid glycosides () and one known analogues () have been isolated and identified from the roots of . The structures of these new compounds were elucidated by extensive spectroscopic analyses (1 D-, 2 D-NMR, HRESIMS, IR, UV) and chemical methods. The anti-inflammatory activities of all isolates were evaluated by measuring their inhibitory effects on PGE production in LPS stimulated RAW 264.
View Article and Find Full Text PDFMolecules
January 2019
School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China.
L. (Asteraceae) is a common and well-known traditional Chinese herbal medicine usually named Cang-Er-Zi, and has been used for thousands of years in China. The purpose of this paper is to summarize the progress of modern research, and provide a systematic review on the traditional usages, botany, phytochemistry, pharmacology, pharmacokinetics, and toxicology of the .
View Article and Find Full Text PDFYakugaku Zasshi
February 2011
Faculty of Pharmaceutical Sciences, Toho University.
This review summarizes the chemoenzymatic synthesis of the biologically active natural products based on a combination of chemical diastereoselectivity and enzymatic enantioselectivity using biocatalyst. Asymmetric reduction of 2-methyl-3-keto ester with yeast gave the optically active syn-2-methyl-3-hydroxy ester, which was converted to natural product such as (-)-oudemansin B. Asymmetric hydrolysis of 3-acetoxy-2-methy esters possessing syn- or anti-structure afforded the optically active 3-hydroxy-2-methyl esters and 3-acetoxy-2-methy esters corresponding to the starting material.
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