AI Article Synopsis
- MMP-10 has been linked to the progression of muscular dystrophy, particularly in the skeletal muscle of young dystrophic mice, but its role in the hearts of dystrophin-deficient mice has not been studied.
- The research focused on the effects of MMP-10 loss in aged dystrophic mice, examining both hind limb muscles and heart tissues.
- Findings revealed that the absence of MMP-10 leads to increased mortality rates in aged mice and a chronic inflammatory response in both skeletal and cardiac muscles, suggesting new avenues for potential therapies targeting muscular dystrophy.
Article Abstract
Matrix metalloproteinases (MMPs) have been implicated in the progression of muscular dystrophy, and recent studies have reported the role of MMP-10 in skeletal muscle pathology of young dystrophic mice. Nevertheless, its involvement in dystrophin-deficient hearts remains unexplored. Here, we aimed to investigate the involvement of MMP-10 in the progression of severe muscular dystrophy and to characterize MMP-10 loss in skeletal and cardiac muscles of aged dystrophic mice. We examined the histopathological effect of MMP-10 ablation in aged mice, both in the hind limb muscles and heart tissues. We found that MMP-10 loss compromises survival rates of aged mice, with skeletal and cardiac muscles developing a chronic inflammatory response. Our findings indicate that MMP-10 is implicated in severe muscular dystrophy progression, thus identifying a new area of research that could lead to future therapies for dystrophic muscles.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8705381 | PMC |
| http://dx.doi.org/10.3390/life11121398 | DOI Listing |
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