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CD8 T cell-Derived Perforin and TNF-α Are Crucial Mediators of Neuronal Destruction in Experimental Autoimmune Enteric Ganglionitis.
Am J Pathol
June 2021
Institute of Neuropathology, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany. Electronic address:
In neuron-specific ovalbumin-transgenic CKTAC mice, antigen-specific OT-I CD8 T cells home to the enteric nervous system, where they attack and destroy neurons of the myenteric and submucosal plexus. Clinically, experimental autoimmune enteric ganglionitis (EAEG) manifests with gastrointestinal dysmotility and rapidly progresses to lethal ileus. Although interferon-γ has been identified as capable of damaging neurons in EAEG, the role of perforin, Fas/FasL, and tumor necrosis factor-α (TNF-α) in this disease is still a matter of debate.
View Article and Find Full Text PDFEsophageal High-Resolution Manometry for Diagnosing the Severity of the Chronic Intestinal Pseudo-Obstruction: A Case Series.
Dig Dis Sci
November 2021
Division of Gastroenterology and Hepatology, Graduate School of Medical and Dental Sciences, Niigata University, 1-757 Asahimachi-dori, Niigata, 951-8510, Japan.
Article Synopsis
- Chronic intestinal pseudo-obstruction (CIPO) is a rare and severe disorder affecting intestinal motility, which has not been well understood due to its complexity and difficulty in studying its pathology.* -
- The study involved 11 CIPO patients, identifying esophageal motility issues through high-resolution manometry (HRM), where five patients showed significant impairments linked to triggers like pregnancy and surgery.* -
- Results suggest that HRM can help assess the severity of CIPO and guide treatment options, with histological findings indicating a correlation between intestinal nerve damage and the clinical severity of the disease.*
Multiple Myeloma Associated Intestinal Amyloidosis: Intestinal Pseudoobstruction Falsely Considered as an Ascites.
Rev Recent Clin Trials
January 2018
Clinic for Gastroenterology and Hepatology, Clinical Center of Serbia, Belgrade, Serbia.
Introduction: Amyloidosis is a group of diseases pathohistologically diagnosed by characteristic extracellular deposition of an abnormal fibrillary protein (i.e. amyloid) into organs, leading to organ dysfunction secondary to destruction of normal tissue architecture.
View Article and Find Full Text PDFClinical, mechanical, and immunohistopathological effects of tissue adhesives on the colon: An in-vivo study.
J Biomed Mater Res B Appl Biomater
May 2017
Department of Surgery, Erasmus University Medical Center, Rotterdam, the Netherlands.
Background: Tissue adhesives may be useful for sealing bowel anastomoses by preventing anastomotic leakage. Prior to clinical implementation, an in-depth analysis of the clinical and immunohistopathological effects of tissue adhesives on the target tissue and of the mechanical strength of the adhesive bond in an in vivo model is needed.
Materials And Methods: In 84 rats, two bowel segments were glued using one of the following tissue adhesive: Bioglue, Gelatin-resorcinol-formaldehyde (GRF), Glubran 2, Histoacryl Flex, Omnex, Duraseal Xact, or Tissucol.
Mortal quintet of sickle cell diseases.
Int J Clin Exp Med
September 2015
Department of General Surgery, Medical Faculty of The Mustafa Kemal University Turkey.
Background: Sickle cell diseases (SCDs) are chronic inflammatory processes on capillary level. We tried to understand some possible correlations between stroke and severity of SCDs.
Methods: All patients with SCDs were taken into the study.
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