In this paper, a novel soft computing technique is designed to analyze the mathematical model of the steady thin film flow of Johnson-Segalman fluid on the surface of an infinitely long vertical cylinder used in the drainage system by using artificial neural networks (ANNs). The approximate series solutions are constructed by Legendre polynomials and a Legendre polynomial-based artificial neural networks architecture (LNN) to approximate solutions for drainage problems. The training of designed neurons in an LNN structure is carried out by a hybridizing generalized normal distribution optimization (GNDO) algorithm and sequential quadratic programming (SQP). To investigate the capabilities of the proposed LNN-GNDO-SQP algorithm, the effect of variations in various non-Newtonian parameters like Stokes number (St), Weissenberg number (We), slip parameters (), and the ratio of viscosities (ϕ) on velocity profiles of the of steady thin film flow of non-Newtonian Johnson-Segalman fluid are investigated. The results establish that the velocity profile is directly affected by increasing Stokes and Weissenberg numbers while the ratio of viscosities and slip parameter inversely affects the fluid's velocity profile. To validate the proposed technique's efficiency, solutions and absolute errors are compared with reference solutions calculated by RK-4 (ode45) and the Genetic algorithm-Active set algorithm (GA-ASA). To study the stability, efficiency and accuracy of the LNN-GNDO-SQP algorithm, extensive graphical and statistical analyses are conducted based on absolute errors, mean, median, standard deviation, mean absolute deviation, Theil's inequality coefficient (TIC), and error in Nash Sutcliffe efficiency (ENSE). Statistics of the performance indicators are approaching zero, which dictates the proposed algorithm's worth and reliability.
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http://dx.doi.org/10.3390/ma14247798 | DOI Listing |
J Int AIDS Soc
February 2025
Centre for Integrated Data and Epidemiological Research, School of Public Health, University of Cape Town, Cape Town, South Africa.
Introduction: Sexually transmitted infections (STIs) in pregnancy are associated with an increased risk of vertical HIV transmission and adverse pregnancy and birth outcomes. In South Africa, syndromic management is the standard of care for STI management. We assessed the potential impact of point-of-care (POC) screening for curable STIs (Chlamydia trachomatis [CT], Trichomonas vaginalis [TV] and Neisseria gonorrhoeae [NG]) during pregnancy on vertical HIV transmission and adverse pregnancy and birth outcomes.
View Article and Find Full Text PDFChem Biol Drug Des
January 2025
Laboratory of Natural Product Chemistry, Department of Pharmacy, Birla Institute of Technology and Science, Pilani (BITS Pilani), Pilani, Rajasthan, India.
A set of coumarin-3-carboxamide analogues were designed, synthesized, and evaluated for their ability to impede pancreatic lipase (PL) activity. Out of all the analogues, 5dh and 5de demonstrated promising inhibitory activity against PL, as indicated by their respective IC values of 9.20 and 11.
View Article and Find Full Text PDFProtein Sci
February 2025
Department of Chemistry and Biochemistry, Center for RNA Biology, The Ohio State University, Columbus, Ohio, USA.
Loz1 is a zinc-responsive transcription factor in fission yeast that maintains cellular zinc homeostasis by repressing the expression of genes required for zinc uptake in high zinc conditions. Previous deletion analysis of Loz1 found a region containing two tandem CH zinc-fingers and an upstream "accessory domain" rich in histidine, lysine, and arginine residues to be sufficient for zinc-dependent DNA binding and gene repression. Here we report unexpected biophysical properties of this pair of seemingly classical CH zinc fingers.
View Article and Find Full Text PDFLiver Int
February 2025
Department of Pediatrics, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.
Background And Aims: Maternal obesity increases the risk of the paediatric form of metabolic dysfunction-associated steatotic liver disease (MASLD), affecting up to 30% of youth, but the developmental origins remain poorly understood.
Methods: Using a Japanese macaque model, we investigated the impact of maternal Western-style diet (mWSD) or chow diet followed by postweaning WSD (pwWSD) or chow diet focusing on bile acid (BA) homeostasis and hepatic fibrosis in livers from third-trimester fetuses and 3-year-old juvenile offspring.
Results: Juveniles exposed to mWSD had increased hepatic collagen I/III content and stellate cell activation in portal regions.
Trop Med Int Health
January 2025
Postgraduate Course in Reabilitação e Desempenho Funcional, Universidade Federal dos Vales do Jequitinhonha e Mucuri (UFVJM), Diamantina, Brazil.
Objective: Chagas disease can cause several complications, such as Chagas cardiomyopathy, the most severe clinical form of the disease. Chagas cardiomyopathy is complex and involves biological and psychosocial factors that can compromise health-related quality of life. However, it is necessary to establish interactions that significantly impact the health-related quality of life of this population.
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