Immunosuppressive Sesquiterpenoids from the Edible Mushroom .

The aim of this work was to comprehensively understand the chemical constituents of the edible mushroom and their bioactivity. A chemical investigation on this mushroom led to the isolation of 23 sesquiterpenoids including eighteen previously undescribed bergamotane sesquiterpenes, craterodoratins A-R (-), and one new victoxinine derivative, craterodoratin S (). The new structures were elucidated by detailed interpretation of spectrometric data, theoretical nuclear magnetic resonance (NMR) and electronic circular dichroism (ECD) calculations, and single-crystal X-ray crystallographic analysis. Compounds and possess a ring-rearranged carbon skeleton. Compounds , , -, , and exhibit potent inhibitory activity against the lipopolysaccharide (LPS)-induced proliferation of B lymphocyte cells with the IC values ranging from 0.67 to 22.68 μM. Compounds and inhibit the concanavalin A (ConA)-induced proliferation of T lymphocyte cell with IC values of 31.50 and 0.98 μM, respectively. It is suggested that is a good source for bergamotane sesquiterpenoids, and their immunosuppressive activity was reported for the first time. This research is conducive to the further development and utilization of .