Scalarane Sesterterpenoids with Antibacterial and Anti-Proliferative Activities from the Mushroom .

Seven undescribed scalarane sesterterpenoids, nambiscalaranes B-H (-), together with two known compounds, nambiscalarane () and aurisin A () were isolated from the cultured mycelium of the luminescent mushroom . Their structures were elucidated by thorough analysis of their 1D and 2D NMR spectroscopic data. The absolute configurations of - were determined by electronic circular dichroism (ECD) calculations and optical rotation measurements. The isolated sesterterpenoids were evaluated against A549, HT29, HeLa, and HCT-116 cancer cell lines, and against five bacterial strains. Compounds , , and showed strong cytotoxicity against HCT-116 cell line, with IC values ranging from 13.41 to 16.53 µM, and showed no cytotoxicity towards cells. Moreover, compound inhibited the growth of with a MIC value of 8 µg/mL, which was equivalent to the MIC value of the standard kanamycin.