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Mapping the Chemistry of Hair Strands by Mass Spectrometry Imaging-A Review. | LitMetric

Mapping the Chemistry of Hair Strands by Mass Spectrometry Imaging-A Review.

Molecules

Lund University Cancer Center, Department of Laboratory Medicine, Lund University, 221 00 Lund, Sweden.

Published: December 2021

AI Article Synopsis

Article Abstract

Hair can record chemical information reflecting our living conditions, and, therefore, strands of hair have become a potent analytical target within the biological and forensic sciences. While early efforts focused on analyzing complete hair strands in bulk, high spatial resolution mass spectrometry imaging (MSI) has recently come to the forefront of chemical hair-strand analysis. MSI techniques offer a localized analysis, requiring fewer de-contamination procedures per default and making it possible to map the distribution of analytes on and within individual hair strands. Applying the techniques to hair samples has proven particularly useful in investigations quantifying the exposure to, and uptake of, toxins or drugs. Overall, MSI, combined with optimized sample preparation protocols, has improved precision and accuracy for identifying several elemental and molecular species in single strands of hair. Here, we review different sample preparation protocols and use cases with a view to make the methodology more accessible to researchers outside of the field of forensic science. We conclude that-although some challenges remain, including contamination issues and matrix effects-MSI offers unique opportunities for obtaining highly resolved spatial information of several compounds simultaneously across hair surfaces.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8706971PMC
http://dx.doi.org/10.3390/molecules26247522DOI Listing

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