AI Article Synopsis
- Zoonotic bacteria pose significant health risks in aquaculture, impacting not only fish but also humans through clinical effects.* -
- A study on 22 isoflavones revealed that adding prenyl groups enhances their antibacterial properties, with some compounds achieving minimum inhibitory concentrations (MIC) of 1.95-500 μg/mL.* -
- The ripe fruit extracts (MTF) showed the greatest antibacterial activity, optimized via specific extraction conditions, making them potential eco-friendly treatments for streptococcosis in aquaculture.*
Article Abstract
zoonotic bacteria cause serious problems in aquaculture with clinical effects on humans. A structure-antibacterial activity relationships analysis of 22 isoflavones isolated from (leaves, ripe fruits, and unripe fruits) against revealed that prenylation of the isoflavone skeleton was an important key for their antibacterial activities (minimum inhibitory concentrations: 1.95-500 μg/mL). Through principal component analysis, characteristic prenylated isoflavones such as 6,8-diprenlygenistein () were identified as pivotal compounds that largely determine each part's antibacterial activities. ripe fruits (MTF), which showed the highest antibacterial activity among the parts tested, were optimized for high antibacterial activity and low cytotoxicity on fathead minnow cells using Box-Behnken design. Optimized extraction conditions were deduced to be 50%/80 °C/7.5 h for ethanol concentration/extraction temperature/time, and OE-MTF showed contents of 6,8-diprenlygenistein (), 2.09% with a MIC of 40 µg/mL. These results suggest that OE-MTF and its active isoflavones have promising potential as eco-friendly antibacterial agents against streptococcosis in aquaculture.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8704674 | PMC |
| http://dx.doi.org/10.3390/molecules26247451 | DOI Listing |
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