A simple example of classical physics may be defined as classical variables, and , and quantum physics may be defined as quantum operators, and . The classical world of p&q, as it is currently understood, is truly disconnected from the quantum world, as it is currently understood. The process of quantization, for which there are several procedures, aims to promote a classical issue into a related quantum issue. In order to retain their physical connection, it becomes critical as to how to promote specific classical variables to associated specific quantum variables. This paper, which also serves as a review paper, leads the reader toward specific, but natural, procedures that promise to ensure that the classical and quantum choices are guaranteed a proper physical connection. Moreover, parallel procedures for fields, and even gravity, that connect classical and quantum physical regimes, will be introduced.
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http://dx.doi.org/10.3390/e23121689 | DOI Listing |
J Med Chem
January 2025
Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, Tennessee 38105, United States.
PROTACs usually occupy physicochemical space outside the one defined by classical drug-like molecules, which often presents considerable challenges in their optimization and development for oral administration. We have previously reported phenyl glutarimide (PG)-based BET PROTAC SJ995973, with improved overall degradation and antiproliferative activities compared to its direct thalidomide-based analogue dBET1, but similarly poor pharmacokinetic profile. To further demonstrate the PG utility, we describe here optimization efforts that led to the discovery of an orally bioavailable BET-PROTAC SJ44236 (), and results of a comprehensive comparative study with analogues containing alternative CRBN-directing warheads.
View Article and Find Full Text PDFSci Robot
January 2025
Department of Bioengineering, Imperial College of London, London, UK.
Despite the advances in bionic reconstruction of missing limbs, the control of robotic limbs is still limited and, in most cases, not felt to be as natural by users. In this study, we introduce a control approach that combines robotic design based on postural synergies and neural decoding of synergistic behavior of spinal motoneurons. We developed a soft prosthetic hand with two degrees of actuation that realizes postures in a two-dimensional linear manifold generated by two postural synergies.
View Article and Find Full Text PDFAngew Chem Int Ed Engl
January 2025
University of Edinburgh, Edinburgh Cancer Research, Crewe Road South, Institute of Genetics and Cancer, EH4 2XR, Edinburgh, UNITED KINGDOM OF GREAT BRITAIN AND NORTHERN IRELAND.
Beyond their classical role as cytotoxics, Platinum (Pt) coordination complexes recently joined the selected group of transition metals capable of performing bioorthogonal reactions in living environments. To minimize their reactivity towards nucleophiles, which limit their catalytic performance, we investigated the use of Pt(0) with different forms, sizes and surface functionalization. We report herein the development of PEGylated Pt nanodendrites with the capacity to activate prodyes and prodrugs in cell culture and in vivo.
View Article and Find Full Text PDFACS Appl Mater Interfaces
January 2025
State Key Laboratory of Powder Metallurgy, Central South University, Changsha 410083, China.
The additive manufacturing of hardmetals has attracted great attention recently but faces significant challenges in low printing resolution and low mechanical strength. Herein, the fabrication of hardmetal parts with complex structures and high surface quality by vat photopolymerization assisted with a sintering process has been achieved. This was enabled by in situ polymerization-induced microencapsulation of WC powder, which simultaneously enhances the photocuring ability and sedimentation stability of the WC-Co slurry.
View Article and Find Full Text PDFQual Life Res
January 2025
PROMENTA Research Center, Department of Psychology, University of Oslo, Oslo, Norway.
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