Microbial contamination is one of the most common food safety issues that lead to food spoilage and foodborne illness, which readily affects the health of the masses as well as gives rise to huge economic losses. In this study, was used as a source of antimicrobial agent that was then analyzed by untargeted metabolomics for its antibacterial mechanism against . The results indicated that the skin mucus extract of had great inhibitory action on the growth of , and the morphology of cells treated with the skin mucus extract exhibited severe morphological damage under scanning electron microscopy. In addition, metabolomics analysis revealed that skin mucus extract stress inhibited the primary metabolic pathways of by inducing the tricarboxylic acid cycle and amino acid biosynthesis, which further affected the normal physiological functions of biofilms. In conclusion, the antimicrobial effect of the skin mucus extract is achieved by disrupting cell membrane functions to induce an intracellular metabolic imbalance. Hence, these results conduce to amass novel insights into the antimicrobial mechanism of the skin mucus extract of against .
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8701811 | PMC |
| http://dx.doi.org/10.3390/foods10122995 | DOI Listing |
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