AI Article Synopsis
- * Macrophages are key players in fibrosis because they can adapt their form and function based on their surrounding environment.
- * The review will explore the significance of different macrophage types in the development of fibrosis in various critical scenarios.
Article Abstract
Fibrosis is a pathophysiological process of wound repair that leads to the deposit of connective tissue in the extracellular matrix. This complication is mainly associated with different pathologies affecting several organs such as lung, liver, heart, kidney, and intestine. In this fibrotic process, macrophages play an important role since they can modulate fibrosis due to their high plasticity, being able to adopt different phenotypes depending on the microenvironment in which they are found. In this review, we will try to discuss whether the macrophage phenotype exerts a pivotal role in the fibrosis development in the most important fibrotic scenarios.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8698841 | PMC |
| http://dx.doi.org/10.3390/biomedicines9121747 | DOI Listing |
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