AI Article Synopsis
- - A 70-year-old man with chronic lymphocytic leukaemia (CLL-B) developed chronic herpes virus infection on his face, characterized by unique cutaneous lesions known as pyodermatitis vegetans.
- - Despite having preserved cell-mediated immunity, the patient showed significant immunodepression indicated by low levels of immunoglobulin.
- - After a successful initial treatment with intravenous acyclovir, the herpes infection recurred 2.5 months later; however, a second treatment with acyclovir also yielded positive results.
Article Abstract
The authors report a case of chronic herpes virus infection of the face which developed in a 70-year old man already affected with chronic lymphocytic leukaemia of the B-cell type (CLL-B) with specific cutaneous localisations. Immunodepression was indicated only by marked hypogammaglobulinaemia. Cell-mediated immunity was preserved. The cutaneous lesions of the face were chronic and presented as pyodermatitis vegetans. A one-week course of acyclovir administered by intravenous infusion in doses of 5 mg/kg three times a day resulted in rapid and dramatic cure, but this result proved transient, since the virus infection relapsed 2 1/2 months later. The new episode also was successfully treated with a second course of acyclovir. The herpes virus infection had developed only on those skin areas that were specifically affected by the leukaemia; after treatment and eradication of the virus, massive lymphocytic infiltration of the dermis persisted in these areas. Involvement of the skin is rare in CLL-B and has been reported mainly in CLL-T. The lesions most frequently encountered are tuberous and papular lesions and infiltrated plaques on the forehead and ears. The pyodermatitis vegetans presentation is unusual. The reasons why viral skin lesions develop on those caused by leukaemia are unknown.
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