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CMV Seropositive Status Increases Heparanase SNPs Regulatory Activity, Risk of Acute GVHD and Yield of CD34 Cell Mobilization. | LitMetric

AI Article Synopsis

  • Heparanase is an enzyme linked to cancer progression and viral infections, acting to promote viral spread and inflammation.
  • Researchers used Single Nucleotide Polymorphisms (SNPs) to explore regulatory regions of the HPSE gene and their impact on conditions like acute graft versus host disease (GVHD) related to cytomegalovirus (CMV) infections.
  • They found that certain SNPs were correlated with CMV positivity in both healthy individuals and cancer patients, indicating that latent CMV infection may influence heparanase's regulatory function in various health outcomes.

Article Abstract

Heparanase is an endo-β-glucuronidase that is best known for its pro-cancerous effects but is also implicated in the pathogenesis of various viruses. Activation of heparanase is a common strategy to increase viral spread and trigger the subsequent inflammatory cascade. Using a Single Nucleotide Polymorphisms (SNP)-associated approach we identified enhancer and insulator regions that regulate HPSE expression. Although a role for heparanase in viral infection has been noticed, the impact of HPSE functional SNPs has not been determined. We investigated the effect of cytomegalovirus (CMV) serostatus on the involvement of HPSE enhancer and insulator functional SNPs in the risk of acute graft versus host disease (GVHD) and granulocyte-colony stimulating factor related CD34 mobilization. A significant correlation between the C alleles of insulator rs4364254 and rs4426765 and CMV seropositivity was found in healthy donors and patients with hematological malignancies. The risk of developing acute GVHD after hematopoietic stem cell transplantation was identified only in CMV-seropositive patients. A significant correlation between the enhancer rs4693608 and insulator rs28649799 and CD34 cell mobilization was demonstrated in the CMV-seropositive donors. It is thus conceivable that latent CMV infection modulates heparanase regulatory regions and enhances the effect of functional SNPs on heparanase function in normal and pathological processes.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8700738PMC
http://dx.doi.org/10.3390/cells10123489DOI Listing

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