() is one of the major human pathogens and the main cause of pathological damages that can progress from chronic gastritis to gastric cancer. During the colonization of gastric mucosa, this bacterium provokes a strong inflammatory response and subsequent oxidative process, which are associated with tissue damage. Therefore, the objective of this research was to evaluate the ability of two olive-leaf extracts (E1 and E2) to modulate the inflammatory response and oxidative stress in -infected human gastric AGS cells. The obtained results showed that both extracts significantly decreased interleukin-8 (IL-8) secretion and reactive oxygen species (ROS) production in human gastric AGS cells. Both extracts also showed antibacterial activity against different strains. HPLC-PAD-MS characterization demonstrated that extract E1 was mainly composed of highly hydrophilic compounds, such as hydroxytyrosol (HT) and its glucosides, and it was the most effective extract as an antibacterial agent. In contrast, extract E2 was composed mostly of moderately hydrophilic compounds, such as oleuropein (OLE), and it was more effective than extract E1 as an anti-inflammatory agent. Both extracts exhibited similar potential to decrease ROS production. These results show the importance of standardizing the extract composition according to the bioactive properties that should be potentiated.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8698654 | PMC |
| http://dx.doi.org/10.3390/antiox10122030 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Efficacy and safety of olive leaf extract (Olea europaea L.) for glycaemic control in adults with type 2 diabetes mellitus (ESOLED): A pilot randomised controlled trial.
Complement Ther Clin Pract
January 2025
Faculty of Health & Education, Torrens University Australia, Bowen Terrace, Fortitude Valley, QLD, 4006, Australia.
Background: Maintaining optimum glycaemic control is essential to reducing comorbidity and mortality in diabetes. However, research indicates that <50 % of patients achieve their target HbA1c ranges. Laboratory studies suggest that olive leaf extract (OLE) may improve glycaemic control, however clinical studies in persons with diabetes are lacking.
View Article and Find Full Text PDFComparative Analysis of Sustainable Extraction Methods and Green Solvents for Olive Leaf Extracts with Antioxidant and Antihyperglycemic Activities.
Antioxidants (Basel)
December 2024
Faculty of Medicine, Nutrition and Dietetics School, Universidad Finis Terrae, Pedro de Valdivia 1509, Providencia, Santiago 7501015, Chile.
Olive leaves are agro-industrial waste that pose an environmental management problem. However, they contain polyphenolic compounds with important bioactive properties beneficial to human. This study aimed to evaluate the effectiveness of two extraction technologies (pressurized liquid extraction and ultrasound-assisted extraction) combined with green solvents (pure water, 15% ethanol, and 15% glycerol) at 50 °C and 70 °C.
View Article and Find Full Text PDFExploration the Effects of Mesenchymal Stem Cells and Olive Leaf Extract on Physiological and Histopathological Changes on the Kidney of Diabetes Rats.
Cell Physiol Biochem
December 2024
Zoology Department, Faculty of Science (Boys), Al-Azhar University, Cairo 11884, Egypt.
Article Synopsis
- Gestational Diabetes Mellitus (GDM) is a common pregnancy complication that can affect renal function and oxidative stress, prompting this study on the potential benefits of olive leaf extracts and stem cells.
- Research involved pregnant rats with induced diabetes to measure various kidney and oxidative stress markers, finding that treatments significantly improved these conditions.
- Results indicated that both treatments not only reduced harmful substance levels but also promoted cellular regeneration and improved kidney tissue structure, suggesting their effectiveness in managing GDM-related complications.
Therapeutic Effect of Mesenchymal Stem Cells and Olive Leaf Extract Against Cytotoxicity Induced by Streptozotocin in Gestational Diabetes Rats.
Cell Physiol Biochem
November 2024
Zoology Department, Faculty of Science, Al-Azhar University, Cairo 11884, Egypt.
Background/aims: Gestational Diabetes Mellitus (GDM), a prevalent complication in pregnancy, is characterized by the Diabetes Association as diabetes diagnosed in the second or third trimester, often remaining asymptomatic. This study investigates the intricate effects of Streptozotocin on pregnant rats, unraveling its impact on Gestational Type 2 Diabetes (GTD). The research delves into the potential therapeutic roles of mesenchymal stem cells (MSCs) and olive leaf extract (OLE) in mitigating the consequences of Streptozotocin-induced pancreatic impairment.
View Article and Find Full Text PDFOlive leaf extract (OLE) reduces mast cell-mediated allergic inflammation.
Biomed Pharmacother
January 2025
Department of Pharmacy, School of Medicine, University of Naples Federico II, Naples, Italy. Electronic address:
Mast cell-mediated reactions promote various allergic disease, including anaphylaxis, allergic rhinitis, asthma, and atopic dermatitis. Different data demonstrated an intricate relationship between the use of antihistaminic drugs, the onset of side effects, and the development of resistance, underscoring the importance to find novel therapeutic approaches to treat allergic diseases. Olive leaf extract (OLE), is a by-product of the olive tree rich in bioactive compounds, known for its numerous therapeutic properties, including antioxidant, anti-tumoral and antidiabetic effects.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!