Aromatic Constituents from the Leaves of with Antioxidant and α-Glucosidase Inhibitory Activity.

As the leaf of has shown antioxidant activity, a study was conducted to identify the active ingredients. Forty-eight compounds were isolated from the leaves of through various chromatographic techniques. Further characterization of the structures on the basis of 1D and 2D NMR and MS data identified several aromatic compounds, including phenylpropanoid derivatives, phenolics, coumarins, flavonoids and lignans. Among them, five compounds were newly reported, naturally occurring, and named argutosides A-D (-), which consist of phenylpropanoid glycosides that are conjugated with a phenolic moiety, and argutoside E (), which is a coumarin glycoside that is conjugated with a phenylpropanoid unit. The isolated compounds showed good antioxidant and α-glucosidase inhibitory activity with differences in activity depending on the structures. Molecular docking analysis demonstrated the interaction between the hydroxyl and carbonyl groups of compounds and with α-glucosidase. Taken together, the leaves of are rich in aromatic compounds with diverse structures. Therefore, the leaves of and their aromatic components might be beneficial for oxidative stress and glucose-related diseases.