AI Article Synopsis
- Glucocorticoids (GCs) affect T cells by causing long-lasting changes in their immune response, particularly during the activation phase.
- *The study found that GCs suppress glycolysis in T cells and increase PD-1 expression, which can hinder their ability to function effectively.
- *Additionally, GCs negatively impact the formation of memory T cells and their anti-tumor activity, indicating a significant alteration in T cell metabolism.
Article Abstract
Glucocorticoids (GCs), immunosuppressive, and anti-inflammatory agents have various effects on T cells. However, the long-term influence of GCs on the T cell-mediated immune response remain to be elucidated. We demonstrated that the administration of GC during the TCR-mediated activation phase induced long-lasting suppression of glycolysis, even after the withdrawal of GC. The acquisition of the effector functions was inhibited, while the expression of PD-1 was increased in CD8 T cells activated in the presence of GC. Furthermore, adoptive transfer experiments revealed that GC-treated CD8 T cells reduced memory T cell formation and anti-tumor activity. These findings reveal that GCs have long-lasting influence on the T cell-mediated immune response via modulation of T cell metabolism.
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| http://dx.doi.org/10.1016/j.bbrc.2021.12.050 | DOI Listing |
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