Longitudinal association between perceived stress and depression among community-dwelling older adults: Findings from the Irish Longitudinal Study on Ageing.

Background: Older adults may be particularly vulnerable to the negative effects of stress on depression. However, the impact of perceived stress on late-life depression is understudied in large community samples. Thus, the present study used data from a population-based sample of Irish older adults to examine the longitudinal association between perceived stress and late-life depression.

Methods: Data from Wave 1 (2009-2011) and Wave 2 (2012-2013) of the Irish Longitudinal Study on Ageing (TILDA) were analyzed. Depression was assessed with the Center for Epidemiologic Studies Depression (CES-D), while the 4-item version of the Perceived Stress Scale was used for perceived stress. Multivariable logistic regression was used to assess the association between perceived stress (exposure) and depression (outcome).

Results: The analytical sample consisted of 5238 individuals aged ≥50 years [mean (SD) age 63.2 (9.1) years; 49.4% females] who did not have depression at Wave 1. The mean perceived stress score at baseline was much lower among those who did not develop depression at Wave 2 compared to those who did (3.85 vs. 6.33). Compared to those in the lowest quartile of levels of perceived stress at baseline, those in the highest quartile had 2.65 (95%CI=1.56-4.49) times higher risk for depression onset.

Limitations: Some baseline information including that of perceived stress could have changed within the two-year follow-up period.

Conclusions: Greater levels of perceived stress at baseline was associated with higher risk for depression onset at two-year follow-up among older adults in Ireland. Individualized interventions addressing stress may be beneficial in the prevention of depression among older adults.