AI Article Synopsis
- Deforestation in South America increases human interaction with toxic caterpillar species, which can induce poisoning through their bristles.
- A study found that caterpillar bristle extract (LOCBE) triggers a pro-inflammatory response in human immune cells known as neutrophils, enhancing their migration and adhesion to tissue proteins.
- LOCBE also leads to a rise in reactive oxygen species (ROS) production and the activation of key inflammatory pathways, suggesting that ROS plays a crucial role in promoting these immune responses.
Article Abstract
The significant incidence of deforestation in South America culminates in the contact of humans with typical forests species. Among these species, one may highlight caterpillar, which, when touched by humans, can poison them through their bristles. Therefore, better acknowledging the mechanisms involved in envenomation caused by caterpillar bristle extract (LOCBE) may contribute to further treatments. Recently, we demonstrated that LOCBE induces a pro-inflammatory profile in endothelial cells; thus, we decided to investigate the effects of LOCBE on human polymorphonuclear neutrophils (PMN), which are the first leukocytes that migrate to the inflammatory focus. Our results showed that treatment with LOCBE induced PMN chemotaxis together with alterations in actin cytoskeleton and focal adhesion kinase (FAK) activation, favoring migration. Concurrently, LOCBE induced PMN adhesion to matrix proteins, such as collagen IV, fibronectin, and fibrinogen. Moreover, we observed that LOCBE attenuated PMN apoptosis and increased reactive oxygen species (ROS) production together with nuclear factor kB (NF-κB) activation-a redox-sensitive transcription factor-as well as interleukin (IL)-1β and IL-8 release. We call attention to the ROS-dependent effect of LOCBE on increased cell migration once an antioxidant treatment reverted it. In summary, we report that LOCBE activates PMN, inducing pro-inflammatory responses modulated by ROS.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8707409 | PMC |
| http://dx.doi.org/10.3390/toxins13120908 | DOI Listing |
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Article Synopsis
- Deforestation in South America increases human interaction with toxic caterpillar species, which can induce poisoning through their bristles.
- A study found that caterpillar bristle extract (LOCBE) triggers a pro-inflammatory response in human immune cells known as neutrophils, enhancing their migration and adhesion to tissue proteins.
- LOCBE also leads to a rise in reactive oxygen species (ROS) production and the activation of key inflammatory pathways, suggesting that ROS plays a crucial role in promoting these immune responses.
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