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Mansouramycins E-G, Cytotoxic Isoquinolinequinones from Marine Streptomycetes. | LitMetric
Chemical investigation of the ethyl acetate extract from the marine-derived sp. isolate B1848 resulted in three new isoquinolinequinone derivatives, the mansouramycins E-G (-), in addition to the previously reported mansouramycins A () and D (). Their structures were elucidated by computer-assisted interpretation of 1D and 2D NMR spectra, high-resolution mass spectrometry, and by comparison with related compounds. Cytotoxicity profiling of the mansouramycins in a panel of up to 36 tumor cell lines indicated a significant cytotoxicity and good tumor selectivity for mansouramycin F (), while the activity profile of E () was less attractive.
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