Extracts of the mantle and viscera of the Indo-Pacific nudibranchs and sp. 1 afforded 11 new diterpenoids (-), all of which possess a tetracyclic spongian-16-one scaffold with extensive oxidation at C-6, C-7, C-11, C-12, C-13, and/or C-20. The structures and relative configuration were investigated by NMR experiments, while X-ray crystallography provided the absolute configuration of , including a 2' configuration for the 2-methylbutanoate substituent located at C-7. Dissection of animal tissue revealed that the mantle and viscera tissues differed in their metabolite composition with diterpenes - present in the mantle tissue of the two nudibranch species.
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